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Scientists at the University of Warwick, jointly with those at Universit茅 Paris-Saclay, Inserm and Assistance Publique-H么pitaux de Paris (France), have challenged the widespread belief that shift workers adjust to the night shift, using data drawn from wearable tech.By monitoring groups of French hospital workers working day or night shif nike dunk ts during their working and free time, the researchers have not only shown that night work significantly disrupts both their sleep quality and their circadian rhythms, but also that workers can experience such disruption even after years of night shift work.Their findings, reported in a study in the Lancet group journaleBio adidas yeezys Medicine,are the most detailed analysis nike dunks high of the sleep and circadian rhythm profiles of shift workers yet attempted, and the first to also monitor body temperature. This key circadian rhythm is driven by the brain pacemaker clock, and coordinates the peripheral clocks in all organs.The research demonstrates the value of telemonitoring SUKKUR:A re newbalance sident of Daleel Khan Korai village claimed on Sunday that the Ghotki police set his house on fire in his absence and took away his 10 goats and cash.The village is situated in the limits of Sarhad police station. The resident, Ali Nawaz Korai, told Mirpur Mathelo-based journalists that a team from Sarhad police station raided his house when no male member was present. He added that after a thorough search, the police took away Rs10,000 along with 10 goats and torched the house before leaving.Meanwhile, the police denied these cha adidas samba hombre rges, claiming that Ali Nawaz was a thief. The head constable of Sarhad police station, Noor Muhammad Kolachi, told reporters that a constable, Kauro Korai, had registered an FIR against Ali Nawaz on charges of theft. "Today, a police party raided his house but as no male member was pr new balance 996 esent in the house, the police left," he claimed.Sarhad SHO Nisar Alam Abro told The Express Tribune that he was on leave and did not know if the police conducted the

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An international team co- yeezys slide led by UdeM computational neuroscientist Eilif Muller has simulated how synapses in the new balance schuhe neocortex change 鈥?to better understa af1 nd how we learn. The 2016 US election cycle is far from maturity, but it is already historic by many standards. The positive aspects a newbalance 550 re that there are more registered voters casting ballots than ever before and that, for the first time, one of the two major parties are set to nominate a fem nb ale presid newbalance ent. The bad news is that despite the best efforts of an invigorated electorate, the voters often found themselves shut out of the nomination process. Mark Twain鈥檚 prophecy comes of age, 鈥淚f voting made any difference, they wouldn鈥檛 let us do it.鈥?The power of the voter has been diminished by the corporate lobbyists and large donors focused on protecting their vested interests and weakening regulation to increase their profits. Somehow Americans are facing a choice between two presidential candidates that the majority of the population despises. According to the RealClearPolitics polling average, Hillary Clinton and Donald Trump have unfavourable ratings of 56 per cent and 59 per cent, respectively. Is thi

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Pr new balance 550 ofessor Mark Lawler, from Queen's University鈥檚 Centre for Cancer Research and Cell Biology is corresponding author of a paper published today in the prestigious international journal Nature Medicine. T converse schuhen he paper highlights the potential of 鈥榖ig data鈥?to unlock the secrets inside cancer cells and enable the development of more effective personalised treatments.Professor Lawler is also Co-Chair of the Cancer Task Team of the Global Alliance for Genomics and Health (GA4GH), which was established in 2013 to create a common framework for the responsible, voluntary and secure sharing of patients鈥?clinical and genomic data.GA4GH is a partnership between scientists, clinicians, patients and the IT and Life Sciences industry involving more than 400 organisations in over 40 countries, and has published today鈥檚 paper as a blueprint to enable the sharing of patient data to improve patient outcomes.Pr asics gel 1130 ofessor Lawler said: 鈥淭he term 鈥榖ig data鈥?refers to huge amounts of information that can be analyse KARACHI:Pakistan Refinery Limited (PRL) posted a net profit of Rs375 million in the quar adidas campus grise ter ended March 31, down 42% f adidas samba uomo rom Rs651 million in the same period last year, according to a company notice sent to the Pakistan Stock Exchange (PSX).Earnings per share (EPS) decreased to Rs1.21 compared to an EPS of Rs2.10 in the same period last year. Cumulatively, in the first nine months (Jul-Mar) of the ongoing fiscal year, the company earned Rs1.06 billion, up by 23% from Rs860 million in the same period last year.The KSE 100-Index closed at 46,874, down 250 points or 0.53% on Tuesday. PRL鈥檚 share price closed at Rs66.23, down 3.6% from Rs68.71.Pakistan Refinery Limited was incorporated in Pakistan as a public limited company in May 1960 and is quoted on Pakistan Stock Exchange (PSX). The refinery is situated on the coastal belt of Karachi. PRL is a hydro skimming refinery designed to process various import newbalance 990 ed and local crude oil to meet the strategic and domestic fuel requirements of the count

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Oral Controlled Release Drug new balance herren Delivery Technology Reports Increased Uptake, Observes Future Market InsightsThe increasing access to healthcare facilities and the bolstering need for drugs to be used orally has been driving the consumption of generic drugs among people across the world, which, in turn, is fueling the need for controlled release technology for drug delivery to suffice the availability of drugs in small dosages. Moreover, the uptake of controlled release drug delivery technology is anticipated to increase further in the near future with a lar yeezy 700 ge pool of drug manufacturers setting up their production unit across various regions, especially in Brazil, Costa Rica, Argentina, and Mexico.Since the combination of several technologies assists in conquering the issues associated with poorly soluble candidates rapidly, the adoption of this technique is also increasing significantly. Being supported th new balance sneaker rough increased sharing of technologies using various symposiums and conferences, w MUMBAI:An Indian court on Friday struck down a tough law that had banned the consumption of beef in the western state of Maharashtra, dealing a blow to right-wing Hindu groups.Last year the government of Maharashtra, home to India's commercial centre Mumbai, made the sale or possession of beef an offence punishable by a five-year jail term or a 10,000-rupee ($150) fine.Indian president approves ban on beef in MaharashtraIt was one of the strictest such laws in India, where several states ban the slaughter of cows, considered sacred by the Hindu majority.However the Bombay High Court, Mumbai's top court, ruled Friday that it was no longer illegal to possess or eat beef, as long as it had been brought into Maharashtra from outside the state.But it adidas samba upheld the adidas campus blanche part of the law, introduced in March 2015, that had extended a 1976 ban on slaughtering cows to cover bulls and bullocks, according to the ruling publishe adidas campus pink d on the court's website."The court has struck down that provision which says t

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A better understanding of how memory works is emerging from a newfound ability to link a learning experience in a mouse to consequent changes in the inner workings of its neurons.Researchers claquette yeezy , supported in part by the National Institutes of Health's National Institute of Mental Health (NIMH), have developed a way to pinpoint the specific cellular components that sustain a specific memory in genetically-engineered mice."Remarkably, this research demonstrates a way to untangle precisely which cells and connections are activated by a particular memory," said NIMH Director Thomas Insel, M.D. "We are actually learning the molecular basis of learning yeezy boost and memory."For a memory to last long-term, the neural connec dunk chaussure tions holding it need to be strengthened by incorporating new proteins triggered by the learning. Yet, it's been a mystery how these new proteins -- born deep inside a neuron -- end up becoming part of the specific connections in far-off neuronal extensions that encode that memory.By tr LAHORE:Pakistan鈥檚 national baseball team will depart for New York tonight from Lahore to take part in World Baseball Classic鈥檚 qualification round scheduled from September 22 to 25.The qualification round will take place at the MCU Park in Brooklyn and will decide the 16th and final entry in the World Baseball Classic event in Los Angeles next year.The 26-member team contingent includes four officials, with Ihsanullah leading the side to play th adidas campus 00's eir adidas campus gr眉n first match against Brazil on September 22.PFB lands hosting rightsPakistan will subsequently face Britain on September 23, and if the national team wins both matches, they will play against Israel on September 25. stanley 鈥淥ur boys have trained very hard during the camp and they are in good shape,鈥?said President of Pakistan Federation Baseball Syed Khawar Shah. 鈥淚t will be a great opportunity for us to earn a name for our country in baseball.鈥滷oreign coach to train baseball teamPakistan Federation Baseball also hired American coach John Goulding fo

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To help biopharmaceutical companies dramatically improve drug development productivity and deliver greater value, Quintiles has announced the acquisition of Expression Analysis, Inc. (EA), a premier provider of genomics t dunk nike high esting and analysis to biopharma, academic, government and non-profit customers.Terms of the transaction were not disclosed. This is the latest in a series of acquisitions and alliances designed to help Quin dunk high nike tiles customers leverage the power of genomics to better understand diseases; develop diagnostic tools; and deliver safer, more effective therapies based on the genetic makeup of the disease and the patient.The addition of EA鈥檚 Genomic Know-How庐 to Quintiles is another step forward in our efforts to bring personalized medicine into mainstream drug development, said Thomas Wollman, Senior Vice President, Quintiles Global Laboratories.Its expertise in genetic sequencing and advanced bioinformat tenis yeezys ics is essential to understanding diseases and drugs at the molecular level Three men accused of raping an Indian woman for a second time were due in court on Wednesd adidas campus blu ay, police said, while the victim's father said his daughter was determined to pursue the case despite the state's failure to protect her.Prosecutors accuse the men of raping the woman, a 20-year-old member of the lower-caste Dalit community, in the north Indi adidas campus noir an city of Rohtak last week.Indian rape survivor gang-raped by same men years laterThe men include two who were arrested for raping her in 2013 and currently out on bail as the case edged its way through India's creaking legal system, police said, while the third was also accused of the earlier attack."We will be collecting DNA samples from the victim and the three accused to ascertain whether the allegations are true... The thre new balance 327 e arrested, they are the same men who had raped her earlier," said Pushpa Khatri, the investigating officer, adding that the woman was in a stable condition.The family have told Indian media that the men had threatene

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Systech International announced its partnership with Tata Consultancy Services (TCS), a provider of world-class IT services and business solutions, to supply the Life Sciences Industry with an effective and economic means of implementing their serialization programs.The partnership couples Systech鈥檚 proven patented technology with TCS鈥檚 ability to provide project management and system integration on a global basis.Debashis Ghosh, President, TCS Life Sciences group said: 鈥淪ystech Seria converse lization converse chucks Technology is recognized as best-in-class by the market. The combination of Systech鈥檚 solutions and TCS鈥?global implementation capability offers a unique proposition to pharmaceutical manufacturers seeking to implement serialization programs.鈥滲arry McDonogh, VP of Business Development, Systech International said: 鈥淪ystech鈥檚 competitive differentiators are in the breadth and maturity of our technology and the ability to embed best-practi jordan 1 mid ce in a serialization implementation. Systech is focusing on d WASHINGTON:The Pentagon will not make the remaining military reimbursements to Pakistan for fiscal year 2016 after US Defence Secretary Jim Mattis Rtold Congress that Islamabad had not taken sufficient action against the Haqqani Network, a US official said on Friday."The funds could not be released to the Government of Pakistan at this time because the secretary could not certify that Pakistan has taken sufficient action agains newbalance 530 t the Haqqani Network per the requirement in the FY 2016 National Defence Authorization Act," Adam Stump, a Pentagon spokesman, said.The decision comes as President Donald Trump's administration is exploring potentially hardening its approach towards Pakistan to crack down on militants launching strikes in neighbouring Afghanistan.'No safe haven': Pakistan rejects US report on Taliban, Haqqani network"This decision does not prejudge the conclusions of the White House review of South Asia strategy, which is still ongoing, adidas schuhe campus " Stump said.However, Pa uggs kistan rejected on

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James dunk nike low C. Foster, Chair nb sneakers 574 man, President, and Chief Executive Officer of Charles River Laboratories, commented, 鈥淭hrough this acquisition, Charles River will provide high-quality research models and associated services to the emerging China market for drug discovery and development. We expect demand for research models in China to significantly increase over the next several years as drug development initiatives in academia, government and biopharmaceutical companies expand. Charles River intends to s air force 1 damen et the standards for research models in China, the third-largest pharmaceutical market in the world, and play a leading role in this emerging opportunity.鈥滱s part of the Vital River acquisition, Charles River will be the exclusive global partner for distribution of model creation services offered through Beijing Vital Star Biotechnology. The services of Beijing Vital Star Biotechnology include humanized model creation utilizing inducible pluripotent stem cell (iPS) and other technologies.Charl LONDON:Manchester United midfielder Bastian Schweinsteiger is set to join Major League Soccer club Chicago Fire, the Chicago Tribune has reported.The German, who signed for United at the start of last season, has found himself out of favour since manager Jose Mourinho arrived at the club at the start of the current campaign.Manchester United's Ibrahimovic banned for three games"Throughout my career, I've always sought opportunities where I hoped to make a positive impact and to help make something great," the newspaper quoted Schweinsteiger as sayin adidas schuhe campus g. "My move to Chicago Fire is no different.鈥滷ire General Manager Nelson Rodriguez said the club were getting a proven winner in Schweinsteig nb 550 er, who spent 13 seasons with Bayern Munich, winning eight Bundes adidas campus rouge liga titles, seven German Cups and the Champions League in 2013.Manchester United's Rashford targets Chelsea revenge mission鈥淗e was also part of the 2014 World Cup winning squad and represented his country 121 times before announcing his r

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Last summer, the Gulf of Mexico鈥檚 鈥渄ead zone鈥?spanned more than 6,400 square miles, more than three times the size it should have been, according to the Gulf Hy nike dunk high poxia Task Force. Nitrogen runoff from farms along the Mississippi River winds up in the Gulf, feeding algae but depriving other marine life of oxygen when the algae decomposes. The 12 states that border the Mississippi have been mandated to develop nutrient reduction strategies, but one especially effective strateg air force 1 y has not been adopted widely: bioreactors.Bioreactors are passive filtration systems that capitalize on a bacterial process known as denitrification to remove from 25 to 45 percent of the nitrate in water draining from farm fields. Research on and installation of bioreactors has accelerated in the past decade, but University of Illinois assistant professor of water quality Laura Christianson a yeezy nd her colleagues are urging a move past proof-of-concept toward large-scale deployment.鈥淏ioreactors are one of the most effec KARACHI:As dust settles on the shocking newbalance 530 announcement that Islamabad United duo Sharjeel Khan and Khalid Latif have been suspended under the Pakistan Cricket Bo adidas samba rose ard鈥檚 Anti-Corruption Code, several experts have weighed in on the controversy that has rocked the Pakis adidas campus damen tan Super League.Sallu praises PCB, calls for strict actionFormer chief selector Salahuddin Sallu praised PCB for acting so swiftly. 鈥淭his is a really good step by the PCB,鈥?he said. 鈥淚t was good to see instantaneous action taken by the board. This shows PCB chairman Shaharyar Khan and league chairman Najam Sethi are determined to make this league successful. This has set an example for other players and very strict action should be taken if they are found guilty.鈥漇allu added that the success of the first edition meant it was always going to be targeted by the bookies.鈥淧layers are always told about how they should act in such situations and asked to inform the PCB鈥檚 Anti-Corruption Unit (ACU) if a suspicious person tries to con

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The results provide another successful proof of concept for the novel approach developed by Oxitec, an Oxford University spinout company pioneering insecticide-free methods to control pest insect populations. The self-limiting gene technique has already been trialled against dengue fever-carrying mosquitos, successfully reducing their populations by over 90% in Brazil, Panama and the Cayman Islan claquette yeezy ds 鈥?an unprecedented level of control by any method, and one that is leading to municipal projects following approval by the national biosafety group in Brazil for releases throughout the country.The approach was inspired by the S asics outlets terile Insect Technique (SIT), which has been used worldwide for more than 50 years, where male insects are sterilize tenis yeezys d by radiation and released to mate with pest females. Without offspring the population crashes. Oxitec鈥檚 approach harnesses the natural reproductive instincts of the male insects, but doesn鈥檛 rely on radiation to sterilize them, which can affect many g LAHORE:Calling upon religious scholars to play an 鈥榚ffective role鈥?in promoting unity and peace in society, Prime Minister Nawaz Sharif has enlisted their help in dispelling the propaganda against the true teachings of Islam.鈥淭errorism cannot be defeated until Ulema play an effective role in carving out a counter narrative against the ideology of terrorists,鈥?Nawaz said on Saturday. He was addressing a seminar at Darul Uloom Jamia N new balance pour homme aeemia in commemoration of the late Mufti Sarfraz Naeemi.鈥淚t is for the reli adidas campus gious scholars to present the true message of our peaceful religion. The need of the hour is to put forward the narrative of our forefathers who made mosques and shrines the centres for peace,鈥?he added.Nawaz said seminaries had newbalance 574 always been the centres of religious education and effective source to dispel any misleading propaganda aimed at creating disharmony among the society.鈥淭hrough a collective effort, Ulema must foil all attempts, aimed at creating fissures in the society and mu

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It is well known that romantic love dunk panda changes the brain, releasing the so-called love hormone oxytocin, responsible for the euphoria we feel when falling in love.Now, researchers from theANU,University of CanberraandUniversity of South Australiahave measured ho yeezy slides w a part of the brain is responsible for putting our loved one on a pedestal in that first flush of romance.In the world鈥檚 first study investigating the link between the human brain鈥檚 behavioural activation system (BAS) and romantic love, researchers surveyed 1556 young adults who identified as being 鈥渋n love鈥?Want more breaking news?Subscribe to Technology Networks鈥?daily newsletter, delivering break air force 1 damen ing science news straight to your inbox every day.Subscribe for FREE PESHAWAR:IGP Nasir Khan Durrani has directed regional police officers to install a biometric system i adidas samba rose n courts as part of security measures.As part of the process, fingerprints of all employees, bar association members, lawyers a adidas campus femme nd visitors will be recorded.聽 Only those whose biometrics can be verified will be allowed to enter court premises.The rest will need to produce summons issued by the court for their hearing.The IGP issued these instructions at the RPOs conference at the Central Police Office on Friday, stated a handout. The CCPO and other officials were present at the meeting which was convened in the wake of the militant attack on Shabqadar courts.According to the handout, RPOs will work to persuade the district and session judges to convene a meeting of bar associations and police to review court safety. Participants at the meeting stanley cups appreciated the role played by the Khyber-Pakhtunkhwa police in the war against terrorism. Sacrifices rendered by the police in terrorism incident

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Menarini-Silicon Biosystems Inc., a developer and manufacturer of technologies and products t dunks hat help uncover the biological complexities of dis卢ease at the single-cell level, and Swift Biosciences, Inc., a developer of innovative technologies for sample preparation for next-generation sequencing (NGS), today announced their collaboration to offer customized NGS products for oncology research and diagnostics. Marketed by Menarini-Silicon Biosystems, the first two products developed for tu yeezy mor cells converse plateau from formalin-fixed, paraffin-embedded (FFPE) tissue samples allow users to obtain high-quality, NGS results from 100 to 300 tumor and stromal cells in an optimized workflow downstream of Menarini-Silicon Biosystems鈥?DEPArray鈩?cell sorting platform.鈥淲e are excited to continue our technology collaboration with Swift Biosciences to offer our cus卢tomers reliable solutions for the genetic analysis of cells derived from FFPE tissue samples,鈥?said Giuseppe Giorgini, CEO of Menarini-Silicon Biosyste YANGON:Rescuers have recovered 14 bodies and expect to find scores more after a ferry packed with teachers, stude nb 530 nts and workers capsized in central Myan stanley cup mar, a local official said Monday.Suu Kyi met Obama in Washington for first time as Myanmar leader"So far we have found 14 dead bodies from the river, but we still need to identify them," director of the local relief and resettlement department, Sa Willy Frient, told AFP, warning that the toll could ri adidas samba vegan se.

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Energy-dense food, obesity and compulsive food intake bordering addiction: the scientific literature has been pointing to connections between these for years. Scientists at the CNRS and Universit茅 de Paris have just shown for the first time how fatty nutrients act on the brain in the reward circuit. These results shed new light on the connection between food and eating disorders.This recent work, directed by scientists at the yeezys Unit茅 de biologie fonctionnelle et adaptative (CNRS/Universit茅 de Paris)12, show that triglycerides, the nutrients t dunk panda hat constitute animal fats, vegetable oils and dairy products, interact with certain neurons in the reward circuit and reduce their excitability in mice, both in vitro and in vivo. These neurons carry a specific type of dopamine-receptor, and their activity strengthens reward-seeking behavior. The scientists also observ nike sb dunk ed that the manipulation of triglyceride levels in the brain of mice changes many behaviors associated with dopamine, like pleasure a ISLAMABAD:The Capital Development Authority (CDA) has finalised arrangements for its upcoming monsoon tree plantation drive with a focus to ensure new balance pour homme participation of people from all walks of life.The CDA Member Environment, Sanaullah Aman, while newbalance 574 chairing a meeting on Monday, said that special arrangements had been made to ensure proper growth of the new balance grise saplings to be planted.In the meeting it was detailed that monsoon tree plantation campaign would be launched on August 29 at Saidpur Range near Shalimar Cricket Ground and a colourful launching ceremony had been planned.People from different walks of life would participate in the event. During the campaign, 300,000 saplings of different species would be planted all over the city.Furthermore, 15,000 fruit trees would be planted at the Lake View Park and special attention would be given to forest area.Published in The Express Tribune, August 23rd, 2016.

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Arrayjet Ltd has announced that Alan Faichney has joined the Board as Non-Executive Chairman with immediate effect.Alan has 33 years of commercial and company leadership experience, building international businesses in the Technology sector.Beginning his career in the jordan schuhe Aerospace industry, Alan later joined the oil exploration industry where he held key technical and strategic roles in product and market development.More recently, Alan held the positions of Managing Direct converse allstar or of Concept Systems Ltd. (a company he co-founded, and grew to a world-leader in the oil exploration business), Senior Vi nike dunk high ce President of Ion Geophysical Inc. (a US publicly quoted company, based in Houston), Chief Operating Officer at DEM-Solutions Ltd., a fast-growing Scottish software start-up with a global market, and Chief Executive Officer of Edinburgh Instruments, a global leader in the supply of high precision scientific instruments, which he recently sold to a publicly quoted Hong Kong company, as well as seve A suspected US drone strike against Islamic State in Afghanistan killed 18 people on Wednesday, most of them militants but possibly including some civilians, Afghan officials said.Civilians casualties in US air strikes against Taliban and other m ugg mini ilitants in Afghanistan have long been a source of friction between the allies who have been stanley fighting since 2001 to end militant opposition to the government in Kabul.Solution to Afghanistan鈥檚 predicament appears nowhere in sightThe strike in Nangarhar province, on the eastern border with Pakistan, killed 18 people, 15 of them militants and three civilians, said Mohammed Ali, police chief of Achin district where the attack occurred."They were in a house to visit someone who had just come from the Hajj pilgrimage," he said. "A drone targeted the house and killed most of them."Provincial police spokesman Hazrat Hussain Mashriqiwal said several Islamic State lead uggs ers had been killed, but he denied there were any noncombatants among the victims.Isla

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AbstractMass spectrometry (MS) has evolved as a critical component in metabolomics which new balance 574 seeks to answer biological new balance f眉r damen questions through large-scale qualitative and quantitative analyses of the metabolome. MS based metabolomics tech yeezy niques offer an excellent combination of sensitivity and selectivity, and they have become an indispensable platform in biology and metabolomics. In this mini review, various MS technologies utilized in metabolomics are briefly reviewed and future needs suggested.The review is published online in the Journal of Biological Chemistry and is free to access. CHENNAI:Police are investigating allegations that a 12-year-old killed herself after a teacher humiliated her for a period stain on her uniform, highlighting the taboo of menstruation in mod ugg hausschuhe ern India.The girl jumped off a building near her home in southern India's Tamil Nadu state on Monday, officials said, leaving a note saying her teacher had tortured her. When other students told the girl she had blood on her clothes, she asked for help. But the fem new balance grise ale teacher made the girl show the stain in class, local media reported her mother assaying.'79% of Pakistani women don't manage periods hygienically'"The teacher did not even take into account that there were boys in the class," The News Minute quoted her as saying. "She asked my daughter to lift (the) top of her salwar (kameez) up and then gave her (a) duster cloth to use as a pad."In India, menstruating women and girls are often considered unclean and impure and are subjected to discrimination stanley during their periods when, for example, th

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TheALS Therapy Development Institute has announced that it has signed a research and development nike dunks agreement with Aptagen LLC, of Jacobus, Penn.Under the terms of the contract, Aptagen will apply its proprietary technology to new balance 9060 develop aptabodies鈩?-- synthetic "molecular bullets" designed to deliver a therapeutic payload to diseased cells.Aptagen's technology will be used as a research tool to expedite drug development in a leading mouse model of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. ALS is a progressive and fatal neurodegenerative disease with no known cause or cure.The integration of aptabodies into the Insti converse schuhe tute's arsenal of technology is an integral part of its scientific plan announced in January. Through its collaboration with the Muscular Dystrophy Association's Augie's Quest ALS initiative, the Institute will apply the aptabody technology in investigating the potential of gene therapy for treating ALS."The use of aptabody conjugates to target a therapeutic t ISLAMABAD:Unshaken by the rise in US interest rates, Pakistan鈥檚 equity markets continue to beat China and India鈥檚 markets by a wide margin. In the last twelve months, Global X MSCI MSCI +% Pakistan ETF was up 16 per cent, beating India鈥檚 and China鈥檚 comparable ETF鈥檚, which boots kaufen were in negative territory for the year, a Forbes recent report said.Market watch: Index ends positive streak, falls below 43,000Highlighting the performance of Index/Fund 12-month of Paki adidas campus verde stan, India, China and others said that Index/Fund of 12-month Performance Global X MSCI Pakistan (NYSE:PAK) was up 16% while iShares China (NYSE:FXI) was -1.5 per cent while iShares of S&P India 50 (NASDAQ:INDY) was-3.24% and iShares MSCI Emerging Markets (NYSE:EEM) was 1.10 per cent, the F adidas samba orbes reported.Pitching Pakistan鈥檚 economy to the worldThe Forbes further reported that Index/Fund 12-month Performance of Global X MSCI Pakistan (NYSE:PAK) was 20 per cent ,iShares China was 9.80 per cent and iShares S&P India 50 was 12.

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Compendia Bioscience, Inc. has announced the central role of their flagship product Oncomine鈩?in the discovery and identification of SPINK1 as a key new therapeutic target and biomarker for prostate cancer.The company believes that the Oncomine is a rapidly growing compendium of nearly 26,000 gene expression and DNA copy numb newbalance schuhe er arrays coupled with analysis functions and a web application for data mining baskets yeezy and visualization. Comprised of thousands of samples representing every major type of cancer, Oncomine exploits this data for therapeutic target discovery, validation, and prioritizatio nike af1 n.Compendia CEO Daniel R. Rhodes, Ph.D., in his continued role as a research investigator at the University of Michigan, led the Oncomine analysis that identified SPINK1 as a candidate oncogene in prostate cancer. Further experimental work by many of the same scientists that previously identified ETS-family gene fusions in prostate cancer using Oncomine led to this discovery.鈥淲e extended an approach calle KARACHI:The Edhis have pledged to donate their organs after death to nb balance carry forward the message of legendary humanitarian Abdul Sattar Edhi.Edhi鈥檚 son Faisal Edhi, the torch-bearer of the Edhi F stanley products oundation, has announced his family would donate their organs to the SIUT, following in the f ugg fellboots ootsteps of his father.Abdul Sattar Edhi鈥檚 eyes were transplanted onto two donors after his death on July 8.Even in death, Edhi gives light to two blind personsOn Saturday, Faisal thanked the SIUT for its services to help his father cope with his prolonged illness over the years at an event organised by the hospital to remember the philanthropist.鈥淎deeb Rizvi and my father developed a fine equation over the years,鈥?he said. 鈥淚t was Rizvi sahib鈥檚 duty to make him understand the importance of going to the hospital for treatment after all efforts of me and my mother failed.鈥滺e then promised his family would also donate their organs to the SIUT 鈥渟o that others may follow this practice and donate organs

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Mycobacteria are a group of pathogenic bacteria that cause diseases like leprosy and tuberculosis in humans. Now, a new study by scientists at Hiroshima University finds that mycobacteria are associated with red blood cells at lung infection sites, an interaction that has escaped scientific notice for 140 years since the discovery of the organism causing tuberculosis. The new research, pu yeezy slide blished on March 16 inMicrobiology Spectrum, illuminated the interaction of mycobacteria with red blood cells and its role in lung disease.Discovery of mycobacteriaIn 1882, German doctor Robert Koch isolated the disease agent nike store dunk that causes tuberculosis (TB) 鈥?a bacteria later namedMycobacterium tuberculosis. His work validated French doctor Jean-Antoine Villemin鈥檚 earlier evidence that tuberculosis was transmissible. While the use of streptomycin to treat TB would wait another 65 years, Koch鈥檚 discovery o nike dunk f the bacterial culprit paved the way for its treatment.M. tuberculosisand other mycobacteria implica KARACHI:A Karachi court sentenced a man to 10 years in prison on Saturday after he was convicted of raping a six-year-old girl two years ago in Korangi.Additional district and sessions judge for district east Zahiba Khattak handed down the sentence to Hamza Khan, a shopkeeper.According to the prosecution, in November 2015, the child went to Khan鈥檚 shop in Korangi to buy candies where he raped her.Minor raped adidas campus 80s , killed and dumped near family home in IslamabadThe court observed that the victim had given an explicit testimony about the incident, while other witnesses ha adidas samba rose d also given statements against Khan and the documentary evidence submitted also proved his crime.Judge Khattak while pronouncing the judgement ordered Khan to pay a fine of Rs50,000. In case he failed to pay, he would undergo six more months of imprisonment.The case was registered under Section 376 (rape) o adidas samba plataforma f the Pakistan Penal Code on the complaint of the child's father.

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Hokkaid yeezy 500 o University researchers have developed a novel method to design and develop peptide antibiotics in large numbers, which will prove critical to controlling antibiotic resistance.Applications of new molecules as drugs are expected to be effective in treating diseases that are difficult to cure with currently used conventional drugs. Peptides are one such type of molecule. They are well s dunk panda tudied, and several drugs have been developed by the modification of different peptides. Modifying and testing new peptide structures is a time-consuming process, so any method that could reduce the time required for this process would rapidly accelerate drug development.Researchers at Hokkaido University led by Assistant Professor Akira Katsuyama new balance f眉r herren and Professor Satoshi Ichikawa at the Faculty of Pharmaceutical Sciences have developed a 鈥渟canning and direct derivatization鈥?method for targeted modification of polymyxin, an antibiotic of last resort. Their work was published in theJournal of the Amer Nawazuddin Siddiqui is saddened by the demise of veteran actor Om Puri. The actor says he was supposed to work with him in Manto.Siddiqui will be bringing the life of Pakistan's short story-writer Sadat Hassan Manto alive on the silver screen through actor and film-maker Nandita Das's project titled Manto. Calling him an inspiration and the best actor in the world, Nawazuddin condoled his death on Twitter.Veteran actor Om Puri passes away at 66Nawazuddin posted, "The best actor in world, An inspiration to me and many, he was suppose to work with me in new balance uomo Manto. Deeply saddened by the news."The Best Actor in World, An inspiration 2 me & many, he was new balance rosa suppose 2 work with me in Manto.Deeply saddened by da news, RIP #OmPuri Saab 馃檹— Nawazuddin Siddiqui (@Nawazuddin_S) Ja adidas campus bianche nuary 6, 2017A Padma Shri awardee and National award-winning talent, Puri died on Friday of heart attack here. He was 66.His work extended from theatre, television, Indian films to those in Britain and the US too.Cele

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Imagine one drug that can target and kill malignant cells for some patients with many types of cancer. A new drug called Vitrakvi (larotrectinib), now approved by the U.S. Food and Drug Administration, shows promise of doing just that for both adults and children with a variety of sometimes rare cancers that share one specific genetic mutation.The mutation, called a TRK fusion, occurs when one yeezy 350 of three NTRK genes becomes mistakenly connected to an unrelated gene and ignites uncontrolled growth. By solely targeting this mutation, the drug is designed to turn off growth signaling with a minimum of other toxicities.According to the drug manufacturer, Loxo Oncology, this specific mutation can occur in a small subset of various adult and pediatric solid tumors ranging from cancers of the appendi yeezy 500 x, bile ducts, breast, lung, pancreas and thyroid to melanoma, GIST and various sarcomas.In certain rare tumor types, such as secretory breast, secretory salivary gland and infantile fibrosarcoma nike dunk nike , TR PESHAWAR:A funding and resour nb 530 ce crunch has hamstrung operations at the Khyber-Pakhtunkhwa Directorate of Human Rights.Despite a surge in the number of human rights cases, funding has largely re nb balance mained the same. A large portion of the funds is spent on staff salaries.聽 Four years ago, the directorate received and resolved some 24 cases. But the figures have swelled since then. More than 300 human rights cases have been catalogued during the first nine months of the current year.An official, who spoke on condition of anonymity, stated that apart from funds the directorate was also not receivi stanley shop ng enough cases.The directorate deals with domestic issues including child labour, honour killing, sexual abuse, and harassment at workplaces, both public and private.Another official said, 鈥渓ack of awareness is the only reason why people don鈥檛 know about the directorate though much of the responsibility lies with us,鈥?adding that they had taken up the matter with the finance ministry but nothing had

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Alnylam Pharmaceuticals, Inc. and collaborators from the David H. Koch Institute for Integrative Research at the Massachusetts Institute of Technology (MIT) announced the publication of yeezy slide new data in the journal Proceedings of the National Academy of yeezy 700 Sciences (PNAS) describing further advancements in discovery and development of novel 鈥渓ipidoid鈥?formulations for the systemic delivery of RNAi therapeutics.Lipidoids are lipid-like materials discovered for the delivery of RNAi therapeutics, and were originally described by Alnylam and MIT collaborators. In particular, the new research findings demonstrate the discovery of new lipidoid materials that facilitate significantly improved in vivo potency for RNAi therapeutics. 鈥淲e are very encouraged with the substantial progress we and our collaborators have made with lipid nanoparticles (LNPs) based on novel lipid-like materials such as lipidoids.鈥濃€淲e are very encouraged with the substantial progress we adidas yeezys and our collaborators have made with lipi DUBAI:Saudi Arabia's powerful deputy crown prince has ruled out any dialogue with Iran, a country he said was busy plotting to control the Muslim world.Prince Mohammed bin Salman, the Saudi defence minister, said in a TV interview to be broadcast later on Tuesday his country could crush Iran-aligned fighters in Yemen where Saudi forces head a coalition of Gulf Arab states interven new balance 740 ing in a civil war.Sunni Muslim Saudi Arabia and Shia Iran compete for influence in the Middle East, supporting rival groups in Syria's civil adidas campus beige ugg fellboots war. In Yemen, Iran denies providing financial or military support to the Houthis who are fighting government forces allied with Saudi Arabia.Pakistan cajoles Iran to join Saudi allianceAsked to respond to reports that after two years of war and Saudi's military intervention the Houthis, aligned to ex-Yemeni president Ali Abdullah Saleh, still control large swathes of Yemen and large quantities of weapons, Prince Mohammed said:"We can uproot the Houthis and Saleh in a ma

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Their success at obtaining a structural map of a protein known as leiomodin 2 (Lmod2) attached to two actin subunits offers a path forward for the study of nemaline myopathy, a hereditary disorder that weakens the muscles and can sometimes be fatal.The work by biochemists Jianpeng Ma and Qinghua Wang and their colleagues appears this week in the Proceedings of the National Academy of Sciences. Ma holds a joint appointment at Rice and Baylor; Wang is at Baylor.Proteins are large molecular chains of amino acids that perform dunk panda many duties in the bo yeezy 350 dy. Knowing how the chains fold into functional proteins helps researchers determine how those involved in causi dunk nike high ng a disease might be addressed with drugs.Obtaining actin鈥檚 structural details in atom-scale resolution had stumped many scientists, Ma said, because the protein鈥檚 rapid growth into an actin filament made it too long to be crystallized.The Rice-Baylor effort came into focus 10 years ago when Ma realized that mutations can be designed to ISLAMABAD:Hussain Haqqani鈥檚 disclosure that he facilitated the stationing of a large number of US special forces and intelligence personnel in Pakistan has vindi new balance rose cated the stance of the country鈥檚 institutions, the military stanley products said on Wednesday in its first formal reaction to the former envoy鈥檚 article in The Washington Post.鈥淰iews of Hussain Haqqani published in a mainstream US newspaper, especially his account on issuance of visas, vindicate the stance of Pakistan鈥檚 state institutions,鈥?Inter-Services Public Relations (ISPR) chief Lt-Gen Asif Ghafoor said in a post on Twitter. 鈥淭he veracity of concerns about his role in the entire issue also stands confirmed,鈥?the military鈥檚 chief spokesman added nb in another tweet.Haqqani, in an opinion piece for The Washington Post earlier this month, admitted he facilitated the stationing of American commandos and spies on Pakistani soil. Classified documents also revealed that then government of Pakistan Peoples Party (PPP) allowed the former ambassador

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A team of researchers at The Scripps Research Institute and other institutions has discovered a new way by which DNA repairs itself, a process that is critical to the protection of the genome yeezy foam , and integral to prevention of cancer development.Scientists who study the repair of the DNA bases, which make up the information in the human genome, had known of only one type of method that cells use to fix a specific kind of damage to their DNA, but in the June 11, 2009 issue of Nature, the team found a novel way - one that combines elements from the known mechanisms and an unrelated second method that was previously not known to play a role in this type of DNA repair."We found a connection between the known DNA repair processes that people air force 1 herren did not know was there," says Professor John Tainer, a member of the Skaggs Institute for Chemical Biology at Scripps Research, who led the study with Geoffrey P. Margison of the University of Manchester yeezy (United Kingdom) and Anthony E. Pegg of the Pennsylva As many as 43 people have died in Tuesday鈥檚 coordinated attack on Istanbul鈥檚 main international adidas campus 00's airport while several others are still receiving treatment in hospitals.The Turkish authorities were quick to point the finger of blame at Islamic State extremists after the Ataturk Airport came under attack by suicide bombers who were armed with automatic rifles.The assault, at the start of Turkey鈥檚 crucial summ samba adidas er tourist season, was the latest in a wave of attacks in Istanbul and the capital Ankara over the past year, putting the country on high alert.Istanbul terrorist attack: Was Turkey napping?In the aftermath of the attack authorities began raids on suspected extremist cells in the country and held 22 people accused of extremist links.However, this is not enough for those who have lost their loved ones in the grisly attack. The victims include passengers, taxi drivers and airport staff.Among the many moving stories and details which have emerged after the deadly at newbalance 550 tack is the last Face

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Rockland Immunochemicals, Inc. expands laboratories to address increased demand for life science research tools. Recognizing the increased demand in its core business segments - nike store dunk antibody products and services - Rockland began planning for its new facility in 2012.Leading architects and contractors in the biopharma industry in and around the Philadelphia area were engaged to plan and to build a technology-friendly 60,000 square foot facility in Limerick, PA.The new location brings Rockland closer to some of its largest biopharma clients, while maintaining its local Pennsylvania roots. The laboratories allow Rockland to build a larger business that delivers value to clients, employees and community.Importantly, the labs are designed with flexible spa yeezy sandales ce where Rockland and nike dunk low its collaborative partners can deliver an expansive selection of services that fulfill the strategic needs of today and the future at an unsurpassed level of quality.A substantial amount of space is reserved within the n NEW YORK:Samsung on Wednesday unveiled a new model of its Galaxy Note as it seeks to leave behind the debacle over exploding batteries in the previous generation of the device, and mount a renewed challenge to Apple and its soon-to-come iPhone 8.Introducing the Note 8 "phablet" at an event in New York City, executives repeatedly thanked fans who had remained loyal to th adidas samba sale e device."None of us will ever forget what happened last year," sai adidas samba adidas d Samsung president of mobile communications business DJ Koh."But, I will never forget how millions of dedicated Note loyalists stayed with us; so let me express my deep adidas samba est gratitude."Android co-founder launches smartphone to compete with iPhone, Galaxy S8The South Korean giant laid claim to being the first smartphone maker to field a "phablet" device -- combining features of smartphones and tablets -- when it introduced the first Note five years ago.Samsung did not disclose the price of the Note 8, which will hit shops on September 15 but will be availab

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Of particular interest to computational chemists working in the pharmaceutical, biotechnology and drug discovery industries, attendees will hear about technologies that guide them to successful small molecule and biotherapeutic drug discovery and development, intuitive molecular design and 3D-QSAR interpret nike sb dunk ation as well as knowledge based toxicity prediction.The keynote presentation will be made by Dr John Overington (EMBL-EBI) with other presentations from Dr. Kim jordan 1 mid ito Funatsu (University of Tokyo), Dr. Yoshio Hamada (Kobe Gakuin Uni low dunks nike versity) and Dr. Hiroshi Chuman (University of Tokushima), Dr. Matt Segall (Optibrium), Dr. Tim Cheeseright (Cresset), Dr. Thierry Hanser (Lhasa Limited) and Dr. Mark Swindells (Chemogenomix). ISLAMABAD:Rig uggs hts defenders have expressed concern over the Peshawar High Court decision declaring the by-elections of Lower Dir valid despite barring of women from voting.A consortium of civil society organisations from across Khyber-Pakhtunkhwa (KP) and Islamabad decided t stanley cup o challenge th ugg boots e PHC verdict, said a聽 statement issued here on Tuesday.Peshawar High Court overturned the Election Commission of Pakistan (ECP) judgement last Thursday saying that the issue is beyond the commission鈥檚 mandate and the petition should have been heard by an election tribunal.The statement said that constitution has been interpreted differently by lawyers, various tiers of the judiciary and the ECP. 鈥淗owever, it is indeed a serious setback to the zealously attained and preserved autonomy and independence of the ECP, and it could have far-reaching consequences in future elections or by-elections,鈥?it said.The statement further said that experts need to discuss whether the constitutionally-guaranteed autonom

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In a proof-of-concept study, researchers from North Carolina State University have pinpointed new compounds that may be effective in containing the virulence 鈥?or ability to produce disease 鈥?of Li new balance schuhe steria, a well-known bacterium that can cause severe food poisoning and even death.Listeria are bacteria most commonly found in soil. Humans come into cont dunk nike store act with Listeria via contaminated meat or milk products and can contract listeriosis, which can lead to severe illness or death 鈥?particularly in very young, elderly and/or immunocompromised populations.Denis Fourches, assistant professor of computational chemistry, postdoctoral researcher Melaine Kuenemann and Paul Orndorff, professor emeritus of microbiology, knew that inhibiting a particular enzyme of Listeria 鈥?known as glucose-1-phosphate uridylyltransferase (GalU) 鈥?led to dramatic modifications of the bacterial cell surface. These chemical modifications in turn rendered the Listeria mu dunk low ch less virulent 鈥?in other words, less able to NEW DELHI:Australian fast bowler Shaun Tait has joined Indian Premier League side Kolkata Knight Riders for the rest of the season, replacing compatriot John Hastings who returned home with an ankle injury.Tait, who went unsold in auctions held in February for IPL teams, joins a long list of Australian players taking part in the latest edition of the cash-rich league.Kolkata chief e campus adidas xecutive Venky Mysore wrote on Twitter and welcomed the former Australian interna adidas campus pink tional.Pleasure to welcome @shaun_tait32 to @KKRiders family. Welcome Taity! pic.twitter.com/Us4NV3Blm1— Venky Mysore (@VenkyMysore) May 11, 2016Cricket commentator Tony Cozier dies at 75The 33-year-old speedster will join fellow Austral adidas samba rose ians Chris Lynn and Brad Hogg at KKR, which is in a strong position to qualify for the playoffs.Tait is set for a second IPL stint after previously representing the former Rajasthan Royals, where he picked up 23 wickets at an average of 27.82 in 21 matches.Tait, who quit one-day internation

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The U.S. Food and Drug Administration (FDA) has granted premarket approval to Thermo Fisher Scientific for the first next-generation sequencing (NGS)-based test that simultaneously screens tumor samples for biomarkers ass yeezys ociated with three FDA-approved therapies for non-small cell lung cancer (NSCLC). Lung cancer is the leading cause of cancer-related deaths in the U.S., with NSCLC accounting for 85 new balance herren percent of all lung cancers.1The Oncomine Dx Target Test simultaneou yeezy sly evaluates 23 genes clinically associated with NSCLC. Following FDA approval, results from analysis of three of these genes can now be used to identify patients who may be eligible for treatment with one of the following: the combined therapy of Tafinlar庐 and Mekinist庐, XALKORI庐, or IRESSA庐. With this test, physicians can now match patients to these therapies in days instead of several weeks, which it often takes when screening samples one biomarker at a time."For people battling non-small cell lung cancer, time is criti President Ashraf Ghani鈥檚 offer of engaging with Pakistan in the backdrop of his US counterpart鈥檚 revised policy on Afghanistan augurs well for both countries. The uggs desire for normalisation of bilateral relations could not have come without a nod from Washington, but reflects realism and needs to be welcome. Kabul ca adidas samba rose nnot afford to bypass Pakistan, however close it may be to India and enjoy the full support of Washington.After the one-sided assessment of Pakistan鈥檚 policies by t adidas samba og he Trump administration, there had to be a carrot and an opening made to break the logjam. Pakistan all along has been insisting on dialogue and improving relations with Afghanistan. Its sincerity was reflected in General Qamar Bajwa鈥檚 several visits to Kabul and meetings with the Afghan leader and his military counterparts. The Foreign Office too has been very active at building bridges. Foreign Secretary Tehmina Janjua鈥檚 recent visit to Kabul where she had very productive meetings with all the key players, includ

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Psychiatrists diagnose people with schizophrenia, ADHD, bipolar disorder and other mental illnesses by spending time with them, looking for the parti nike dunk cular behavior symptoms of each. What follows can be a hit-or-miss series of medications and dosages until disruptive behaviors go away.By deciphering the circuitry of the medial frontal cortex 鈥?an area beneath the top of the head 鈥?those diagnoses could become much more efficient and precise by allowing physicians to diagnose based on how neurons respond to a simple series of behavior tests.A Vanderbilt University team recently described how error and reward signals are organized within the cerebral cortex, which is only as thick as a nickel. They say this information could also be significant in drug development by dunk nike low guiding medications to target receptors in particular lay nike dunk panda ers of the cerebral cortex where they will be most effective.In a paper titled 鈥淐ortical Microcircuitry of Performance Monitoring,鈥?their findings were published today LONDON:Pe adidas samba vegan ople who smoke marijuana have a聽three times greater risk of dying from hypertension, or high聽blood pressure, than those who have never used the drug,聽scientists said on Wednesday.The risk grows with every year of use, they said. The findings, from a study of some 1,200 people, could have聽implications in the United S adidas samba adidas tates among other countries. Several聽states have legalised marijuana and others are moving towards聽it. It is decriminalised in a number of other countries. "Support for liberal marijuana use is partly due to claims聽that it is beneficial and possibly not harmful to health," said聽Barbara Yanke adidas samba rose y, who co-led the research at the school of public聽health at Georgia State University in the United States.Saying no to drugs: Lahore gets Pakistan鈥檚 largest addicts treatment centre"It is important to establish whether any health benefits聽outweigh the potential health, social and economic risks. If聽marijuana use is implicated in cardiovascular diseases and聽deaths, then it rests

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